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    ‘ME/CFS is no more an enigmatic disease for which therapeutic concepts are missing..... there is a good chance of novel, highly efficacious drugs and even healing for this frequent and most debilitating disease. We appeal to politicians, pharmaceutical companies and stakeholders to support the rapid development of such promising new drugs.'

    – Prof. Klaus Wirth & Prof. Carmen Scheibenbogen, p. 387.

  • Explaining the most exciting recent ME/CFS research & providing concrete steps to improve quality of life

    Has the mystery of ME/CFS finally been solved?

    For decades, Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) has remained a medical enigma—misunderstood, misdiagnosed, and often dismissed. But breakthrough research might finally be changing that.

    In this accessible and hopeful guide, ME/CFS patient Patrick Ussher distills the groundbreaking work of Professors Klaus Wirth and Carmen Scheibenbogen, who have proposed a compelling unifying model of ME/CFS. This new understanding brings together multiple dysfunctions—low blood volume, microclots, mitochondrial damage, autoimmunity, and more—into one interconnected cycle. It may, at last, explain why so many suffer from post-exertional malaise, brain fog, and relentless fatigue.

    More than just theory, this book offers practical healing strategies:

    - Breathing techniques like the Buteyko Method

    - Ancestral nutrition and gut repair

    - Microclot treatment options

    - The Perrin technique

    - Promising future medications—especially the new ‘Mitodicure’ pill, which could become the first drug specifically for ME/CFS

    Patrick also shares his own story of living with ME/CFS and what has helped him most—physically and emotionally. His goal is simple: to empower fellow patients with knowledge, practical tools, and renewed hope.

    Whether you have ME/CFS or Long Covid, this book will help you understand your illness—and imagine a life beyond it.

    Includes a foreword by Prof. Klaus Wirth who is developing the ‘Mitodicure’ pill

  • About the author

    Patrick Ussher has had ME/CFS for seven years. He has a YouTube channel, 'Understanding ME-CFS', in which he talks about the research into ME/CFS and Long Covid in an accessible way and in which he shares treatment strategies that he has tried.

    He has also written a medical hypothesis on the potential causes of excessive thirst in ME/CFS and Long Covid and why this symptom has likely been historically misdiagnosed as 'psychogenic water drinking'. He also gives regular talks to patient groups such as The Irish ME Trust and has written for the ME/CFS blog, Health Rising, on various topics.

    These talks and papers - as well as information on Patrick's other books and music - can be found on Patrick's main personal website.

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  • PRAISE FOR THE BOOK

    “In Understanding ME/CFS & Strategies for Healing, Patrick Ussher skillfully integrates a huge amount of research that at first glance looks unrelated. From it, he communicates a unique and compelling hypothesis about what is going on in ME/CFS and how to recover. Ussher supplements the science with his own personal journey of improvement and that of other patients. Understanding ME/CFS is a respectful, balanced and very readable book for both practitioners and lay readers”.

    Dr. Eleanor Stein MD FRCP(C), Canadian physician with 35+ years-experience in the field and former ME/CFS patient. Online educator for ME/CFS and related illnesses.

    "I have been strongly impressed by the high scientific level of Patrick’s writings on ME/CFS, particularly considering his non-medical background and the short time that he could have worked on this area. I welcome the publication of his book which seeks particularly to explain the research by myself and Prof. Scheibenbogen in an accessible way for a patient audience, as well as talking about other facets of the illness and ways to improve quality of life."

    Prof. Klaus Wirth, Chief Scientific Officer of Mitodicure & Adjunct Professor in Pharmacology, Goethe University, Frankfurt (from the book's Foreword)

    "I wholeheartedly recommend this book to anyone seeking to enhance their quality of life or to better understand possible pathways to improvement for conditions like ME/CFS, Long COVID, or other post-acute infection syndromes. Patrick Ussher’s work is a beacon of hope, offering both scientific understanding and tangible solutions for those in need.”

    Prof. Peter Deen, Professor in Metabolic Physiology of the Radboud university, Nijmegen, The Netherlands and CEO of Streasure4Health, a start-up developing diagnostics for ME/CFS, Long Covid and Other Post-Acute Infection Syndromes

    "I had many light bulb moments reading this book and would highly recommend it for those living with ME/CFS or Long Covid, their families, carers and health professionals. For those with cognitive dysfunction, the chapter summaries are also extremely helpful to refer to."

  • To buy the book, you have two choices at present:

    - Through all major online retailers in e-book and paperback. Click here to see options. There is also an audiobook version available from Kobo and now from Amazon Audible.

    - Your local book shop should be able to order a copy for you, as the book is published through worldwide distributor IngramSpark.

  • CONTACT / NEWSLETTER

    I welcome media enquiries (podcast, radio appearences and review copies, etc). I also love hearing from my readers. Please drop me a line.

    If you wish to join my newsletter for important updates relating to this book and my ME/CFS work, please fill in the contact box but just write 'newsletter' in the message section.

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